- Title
- The association between patterns of early respiratory disease and diastolic dysfunction in preterm infants
- Creator
- de Waal, Koert; Crendal, Edward; Poon, Amy Chin-Yu; Latheef, Mariyam Shaya; Sachawars, Elias; MacDougall, Thomas; Phad, Nilkant
- Relation
- Journal of Perinatology Vol. 43, p. 1268-1273
- Publisher Link
- http://dx.doi.org/10.1038/s41372-023-01608-5
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2023
- Description
- Background: This study aims to determine the association between clinical patterns of early respiratory disease and diastolic dysfunction in preterm infants. Methods: Preterm infants <29 weeks’ gestation underwent cardiac ultrasounds around day 7 and 14–21. Respiratory dysfunction patterns were classified as stable (ST), respiratory deterioration (RD) or early persistent respiratory dysfunction (EPRD) according to oxygen need. Diastolic dysfunction was diagnosed using a multi-parameter approach including left atrial strain (LASR) to help differentiate between cardiac or pulmonary pathophysiology. Results: 98 infants (mean 27 weeks) were included. The prevalence of ST, RD and EPRD was 53%, 21% and 26% respectively. Diastolic dysfunction was more prevalent in the RD and EPRD groups with patent ductus arteriosus and significant growth restriction as risk factors. Not all infants with a PDA developed diastolic dysfunction. LASR was lower in the EPDR group. Conclusion: Respiratory dysfunction patterns are associated with diastolic dysfunction in preterm infants.
- Subject
- early respiratory disease; preterm infants; diastolic dysfunction; risk factors; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1494504
- Identifier
- uon:53815
- Identifier
- ISSN:0743-8346
- Rights
- x
- Language
- eng
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